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Catalog ID sC5b9 Soluble Complement 5b-9 (sC5b-9)

Additional Codes

CPOE: Ref Specimen Misc; specify sC5b-9

Specimen

EDTA Lavender top tube, collect 2.0 mL blood

Plasma, 1.0 mL (0.5 mL minimum), frozen

***Must centrifuge and separate from cells within 1 hour of collection.***

Rejection Criteria

Serum, other anticoagulant, not centrifuged and separated from cells <1 hour from collection, room temperature specimen, refrigerated specimen, insufficient quantity, unlabelled specimen

Interpretative Information

Elevations in soluble Complement 5b-9 (sC5b-9) have been associated with increased activation of the alternative complement pathway. Increased complement activation may be seen with aHUS and other TMAs, and may be a sensitive early predictor of the development of transplant associated TMA. In a cohort of 67 pediatric patients who had an allogeneic HSCT, an increase in sC5b-9 concentration from baseline had 100% sensitivity and 53% specificity for TA-TMA.

Performing Lab

Machaon Diagnostics

Turn-Around-Time

<24 hours from specimen receipt at Machaon Diagnostics

Reference Values

<250 ng/mL