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HelpCatalog ID TSTGP Tissue Transglutaminase Antibodies, IgA and IgG Profile, Serum
Useful For
Evaluating patients suspected of having celiac disease, including patients with compatible clinical symptoms, patients with atypical symptoms, and individuals at increased risk (family history, previous diagnosis with associated disease, positivity for HLA DQ2 and/or DQ8)
Screening for dermatitis herpetiformis, in conjunction with endomysial antibody test
Monitoring response to gluten-free diet in patients with dermatitis herpetiformis and celiac disease
Specimen Type
SerumCollect 1.0 mL blood in Gold top tube.
Reference Values
tTG ANTIBODY, IgA
<4.0 U/mL (negative)
4.0-10.0 U/mL (weak positive)
>10.0 U/mL (positive)
Reference values apply to all ages.
tTG ANTIBODY, IgG
<6.0 U/mL (negative)
6.0-9.0 U/mL (weak positive)
>9.0 U/mL (positive)
Reference values apply to all ages.
Day(s) Performed
Monday through Saturday
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | OK |
Reporting Name
Tissue Transglutaminase Ab, IgA/IgGProfile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| TTGA | Tissue Transglutaminase Ab, IgA, S | Yes | Yes |
| TTGG | Tissue Transglutaminase Ab, IgG, S | Yes | Yes |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Ordering Guidance
Cascade testing is recommended for celiac disease. Cascade testing ensures that testing proceeds in an algorithmic fashion. The following cascades are available; select the appropriate one for your specific patient situation.
-CDCOM / Celiac Disease Comprehensive Cascade, Serum and Whole Blood: complete testing including HLA DQ
-CDSP / Celiac Disease Serology Cascade, Serum: complete serology testing excluding HLA DQ
-CDGF / Celiac Disease Gluten-Free Cascade, Serum and Whole Blood: for patients already adhering to a gluten-free diet
To order individual tests, see Celiac Disease Diagnostic Testing Algorithm
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 21 days | |
| Frozen | 21 days |
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86364 x 2
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| TSTGP | Tissue Transglutaminase Ab, IgA/IgG | 35681-6 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| TTGA | Tissue Transglutaminase Ab, IgA, S | 46128-5 |
| TTGG | Tissue Transglutaminase Ab, IgG, S | 56537-4 |
Testing Algorithm
The following algorithms are available:
-Celiac Disease Comprehensive Cascade Test Algorithm
-Celiac Disease Diagnostic Testing Algorithm
-Celiac Disease Gluten-Free Cascade Test Algorithm
Method Name
Enzyme-Linked Immunosorbent Assay (ELISA)
Special Instructions
Forms
If not ordering electronically, complete, print, and send a Gastroenterology and Hepatology Test Request (T728) with the specimen.