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Catalog ID Sirolimus Level Sirolimus

CPOE Test Name

Sirolimus Level

Epic EAP Test Code

LAB875

Synonyms

Sirolimus; rapamycin

Specimen Type

Plasma

Specimen Requirements

4.0 mL (EDTA) Lavender top 2 mL blood

Causes for Rejection

Wrong specimen type; lack of acceptable patient labeling.

Turn Around Time

12 hours from testing.

CPT / HCPCS Code

80197

Performing Lab

Core Laboratory BI 2023 721-2120

Reference Values

3.0 ng/dL to 15.0 ng/dL

Critical Values

Toxic Level: >20.0 ng/dL

Storage and Transport

Specimens may be stored for up to 14 days at 2-8C prior to being tested. Transport to SCC lab or Receiving, who will then order and deliver to Chemistry.

Interpretation

The complexity of the clinical state and individual differences in sensitivity to the immunosuppressive effects of rapamycin/sirolimus will cause different requirements for optimal whole blood levels of rapamycin/sirolimus. Individual whole blood rapamycin/sirolimus values cannot be used as the sole indicator for making changes in the treatment regimen. Each patient should be thoroughly evaluated clinically before treatment adjustments are made and each user must establish his or her own ranges based on these clinical findings.

Methodology

MEIA

Test Consists

The quantitation of levels for rapamycin/sirolimus