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Catalog ID Pancre Pancreastatin, Serum

Additional Codes

CPOE: Ref Pancreastatin, Serum

DOE: Ref Pancrea

CPT Code

86316

Specimen

Patient must be fasting 10-12 hours prior to collection. Patient should not be on any medications that may influence insulin levels, if possible, for at least 48 hours prior to collection.

Gold SST tube, collect 4 mL blood, allow specimen to clot for 2 hours at room temperature prior to centrifugation

Serum, 2 mL (1 mL minimum), frozen

Rejection Criteria

Plasma, urine, room temperature specimen, refrigerated specimen, frozen thawed in transport specimen, insufficient quantity, unlabelled specimen.

Interpretative Information

Pancreastatin is a 49 amino acid peptide produced by degradation of Chromo-granin A. It inhibits Chromogranin A and Parathyroid Hormone release. Pancreastatin also inhibits release of Somatostatin upon glucose stimulation. It may also control carbohydrate metabolism and hyperglycemia. Although there are no compounds with significant structural homology with Pancreastatin, there are minor similarities to Gastrin and Anti-Diuretic Hormone. Pancreastatin reduces the early phase of Glucose induced Insulin release.  Suppression of Insulin release upon Glucose stimulation is a characteristic feature of Type II Diabetes. Pancreastatin could play an important therapeutic role in the treatment of diabetes. Pancreastatin also inhibits release of Somatostatin. It may also control carbohydrate metabolism and hyperglycemia.

Performing Lab

BioAgilytix Diagnostics via ARUP Laboratories

Turn-Around-Time

7-10 days

Reference Values

100.0 - 288.7 pg/mL