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Catalog ID NMDAR N-methyl-D-Aspartate Receptor Antibody, IgG CBA-IFA, Serum with Reflex to Titer

Important Note

CSF is more sensistive in NMDA-R Antibodies and is the preferred test for NMDA-R encephalopathy.

Additional Codes

CPOE: Ref N-methyl-D-Aspartate Receptor Antibody, IgG CBA-IFA, Serum with Reflex to Titer

DOE: Ref NMDAR Ser

Specimen

Gold SST tube, collect 2.0 mL blood

Centrifuge specimen within 2 hours of collection

Serum, 1.0 mL (0.15 mL minimum), refrigerated

Rejection Criteria

CSF, plasma, contaminated specimen, hemolyzed specimen, severely lipemic specimen, specimen not centrifuged <2 hours from collection, specimen at room temperature >48 hours after collection

Interpretative Information

Anti-NMDA receptor IgG antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of autoimmune limbic encephalitis.

If NMDA antibody IgG is positive, then an NMDA antibody IgG titer is reported. Additional charges apply.

Performing Lab

ARUP Laboratories

Turn-Around-Time

1-3 days from ARUP Laboratories specimen receipt

Reference Values

Less than 1:10