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HelpCatalog ID NIS Nickel, Serum
Useful For
Confirmation of an elevated urinary nickel concentration
This test is not useful for the investigation of nickel hypersensitivity.
Ordering Guidance
Urine is the preferred specimen type for determining nickel exposure and potential toxicity. Order NIU / Nickel, 24 Hour, Urine or NIUCR / Nickel/Creatinine Ratio, Random, Urine.
This test should not be ordered for the investigation of nickel hypersensitivity. Instead, order testing for lymphocyte proliferation to nickel.
Specimen Required
Patient Preparation: High concentrations of gadolinium and iodine are known to interfere with most metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Supplies: Metal Free Specimen Vial (T173)
Collection Container/Tube: Royal blue-top (metal-free, no additive)
Submission Container/Tube: 7-mL Mayo metal-free, screw-capped, vial
Specimen Volume: 0.5 mL
Collection Instructions:
1. Allow the specimen to clot for 30 minutes; then centrifuge the specimen to separate serum from the cellular fraction.
2. Remove the stopper. Carefully pour specimen into a Mayo metal-free, screw-capped vial, avoiding transfer of the cellular components of blood. Do not insert a pipet into the serum to accomplish transfer, and do not ream the specimen with a wooden stick to assist with serum transfer.
3. See Metals Analysis Specimen Collection and Transport for complete instructions.
Collect full Dark Blue top tube WITH THE RED STRIPE ON THE LABEL
Specimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 7 days | METAL FREE |
| Ambient | 7 days | METAL FREE | |
| Frozen | 7 days | METAL FREE |
Reference Values
<2.0 ng/mL
Day(s) Performed
Thursday
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83885
Reporting Name
Nickel, SSpecimen Type
SerumPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Special Instructions
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| NIS | Nickel, S | 5702-6 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8622 | Nickel, S | 5702-6 |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Method Name
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)