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Catalog ID MSNER Motor and Sensory Neuropathy Evaluation with Reflex to Titer and Neuronal Immunoblot

Additional Codes

CPOE: Ref Motor and Sensory Neuropathy Evaluation with Reflex to Titer and Neuronal Immunoblot

DOE: Ref Mot Sens

Specimen

Gold SST tube, collect 4.0 mL blood

Centrifuge within 2 hours of collection

Serum, 2.0 mL (1.0 mL minimum), refrigerated

Rejection Criteria

Plasma, CSF, other body fluids, contaminated specimen, heat-inactivated specimen, hemolyzed specimine, severly icteric specimen, lipemic specimen, insufficient quantity, unlabelled specimen, specimen room temperature >24 hours, specimen not centrifuged <2 hours

Interpretative Information

Aid in diagnosis of combined motor/sensory neuropathy when malignancy, other than plasma cell dyscrasia, is suspected.

Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. Additional charges apply.

Performing Lab

ARUP Laboratories

Turn-Around-Time

1-9 days

Reference Values

Component Result Interpretation
Asialo-GM1 Antibodies, IgG/IgM 29 IV or less Negative
  30-50 IV Equivocal
  51-100 IV Positive
  101 IV or greater Strong Positive
GM1 Antibodies, IgG/IgM 29 IV or less Negative
  30-50 IV Equivocal
  51-100 IV Positive
  101 IV or greater Strong Positive
GD1a Antibodies, IgG/IgM 29 IV or less Negative
  30-50 IV Equivocal
  51-100 IV Positive
  101 IV or greater Strong Positive
GD1b Antibodies, IgG/IgM 29 IV or less Negative
  30-50 IV Equivocal
  51-100 IV Positive
  101 IV or greater Strong Positive
GQ1b Antibodies, IgG/IgM 29 IV or less Negative
  30-50 IV Equivocal
  51-100 IV Positive
  101 IV or greater Strong Positive