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Catalog ID IgG Immunoglobulin G (Serum)

CPOE Test Name

IgG

Synonyms

Quantitative IgG

Specimen Type

Serum

Specimen Requirements

5 mL gold top SST tube; 3 mL blood

Storage and Transport

Specimen may be stored at 2 – 8° C for up to 72 hours prior to testing. Specimens in which testing will be delayed for longer than 72 hours should be frozen at -15° C or colder, avoid multiple freeze thaw cycles.

Reference Values

0-<5 months: 100-334 mg/dL
5-<9 months: 164-588 mg/dL
9-<15 months: 246-904 mg/dL
15-<24 months: 313-1,170 mg/dL
2-<4 years: 295-1,156 mg/dL
4-<7 years: 386-1,470 mg/dL
7-<10 years: 462-1,682 mg/dL
10-<13 years: 503-1,719 mg/dL
13-<16 years: 509-1,580 mg/dL
16-<18 years: 487-1,327 mg/dL
≥18 years: 767-1,590 mg/dL

Interpretation

Elevated levels of IgG can occur from a variety of reasons including a broad spectrum of infectious diseases and immune reactive states such as autoimmune/collagen diseases. Extremely high levels may be found in multiple myeloma.

Decreased levels of IgG can be found in immunodeficiency. The immunodeficiency may be the result of a hereditary deficiency or an acquired deficiency resulting from situations such as HIV disease, chemotherapy, etc. IgG is made up of four different subclasses. One or more of these subclasses may be deficient in the presence of normal levels of total IgG. See Additional Information below.

Causes for Rejection

Gross lipemia; improper labeling; insufficient quantity; improper tube

CPT / HCPCS Code

82784

Performing Lab

Core Laboratory BI 2023 721-2120

Test Consists

The quantitative determination of total IgG in serum.