Sign in →

Catalog ID HMGCR 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) Antibody, IgG

Additional Codes

CPOE: Ref 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) Antibody, IgG

DOE: Ref HMGCR

Specimen

Gold SST Tube, collect 1.0 mL blood

Serum, 0.5 mL (0.2 mL minimum), refrigerated

Rejection Criteria

Plasma, other body fluids, contaminated specimen, hemolyzed specimen, grossly icteric specimen, severely lipemic specimen, specimen at room temperature >48 hours, insufficient quantity, unlabelled specimen

Interpretative Information

IgG antibodies to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are mainly associated with necrotizing autoimmune myopathy (NAM) in a subset of statin-treated patients. Although infrequent, these antibodies may also be observed in statin-naive patients with NAM. Strong clinical correlation is recommended in the absence of muscle fiber necrosis, elevated serum creatine kinase, perimysial pathology, and/or statin exposure.

Performing Lab

ARUP Laboratories

Turn-Around-Time

1-15 days (testing is performed on Fridays)

Reference Values

0-19 Units = Negative