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HelpCatalog ID FYABS Yo Antibody Screen with Reflex to Titer and Western Blot
Specimen Required
Draw blood in a plain red-top tube(s), serum gel tube(s) is acceptable. Spin down and send 0.5 mL of serum ambient in a plastic vial.
Note: Overnight fasting is preferred.
Collect 1.2 mL blood in Red top tube. Patient should fast for 8 hours prior to draw.
Reference Values
Yo Ab, IFA: Negative
Purkinje cells cytoplasmic antibody (Yo) can be found in approximately 50% of patients with paraneoplastic cerebellar degeneration (PCD). The presence of Yo antibody strongly suggests underlying gynecological cancer primarily of ovarian or breast origin. A negative assay for Yo antibody does not exclude the possibility of a malignant tumor.
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| FYABW | Yo Ab, Western Blot | No | No |
| FYABT | Yo Ab Titer | No | No |
Day(s) Performed
Monday, Wednesday, Friday
Reject Due To
| Hemolysis | Mild OK; Gross reject |
| Lipemia | Mild reject; Gross reject |
| Icterus | Mild OK; Gross reject |
| Other | NA |
Method Name
Immunofluorescence Assay (IFA)
Western Blot (WB)
Reporting Name
Yo Ab Scr. w/Reflex to Titer and WBSpecimen Type
SerumSpecimen Minimum Volume
0.2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Ambient (preferred) | 7 days | |
| Frozen | 21 days | ||
| Refrigerated | 14 days |
Performing Laboratory
Quest Diagnostics Nichols InstituteTest Classification
This test was developed and its performance characteristics have been determined by Quest Diagnostics Nichols Institute, San Juan Capistrano. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Performance characteristics refer to the analytical performance of the test.Testing Algorithm
If Yo Antibody Screen, IFA is positive, Yo Ab, Western Blot, FYABW, will be performed at an additional charge.
If Yo Antibody, Western Blot is positive, Yo Ab Titer, FYABT, will be performed at an additional charge.
CPT Code Information
86255-Screen
84181-Western Blot with interpretation and report (if appropriate)
86256-Titer, each antibody (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| FYABS | Yo Ab Scr. w/Reflex to Titer and WB | 14249-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| Z3692 | Yo Ab, IFA | 14249-7 |