Catalog ID FFCAH Congenital Adrenal Hyperplasia (CAH) Pediatric Profile 6, Comprehensive Screen
Specimen Required
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 3.5 mL Serum
Collection Instructions:
1. Within 45 minutes of collection, centrifuge and aliquot serum into a plastic vial.
2. Send frozen.
Additional Information: To avoid delays in turnaround time when requesting multiple tests, submit separate frozen specimens for each test requested.
Collect 7.0 mL blood in Red top tube.
Secondary ID
75305Method Name
High Pressure Liquid Chromatography/Tandem Mass Spectrometry (HPLC/MS-MS)
Reporting Name
CAH Profile 6Specimen Type
Serum RedSpecimen Minimum Volume
Serum: 2 mL Note: This volume does not allow for repeat testing.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Frozen | 90 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icteric | Reject |
Reference Values
Androstenedione:
Premature (26-28 weeks) Day 4: 63-935 ng/dL
Premature (31-35 weeks) Day 4: 50-449 ng/dL
Full Term (1-7 days): <10-279 ng/dL
Levels decrease rapidly to <52 ng/dL after one week.
1 month-11 months: <10-37 ng/dL
Androstenedione gradually decreases during the first six months to prepubertal levels.
Prepubertal Children: <10-17 ng/dL
Adults
Males: 44-186 ng/dL
Females: 2 -230 ng/dL
Females Postmenopausal: <10-93 ng/dL
Cortisol:
Premature (26-28 weeks) Day 4: 1.0-11 ug/dL
Premature (31-35 weeks) Day 4: 2.5-9.1 ug/dL
Full Term Day 3: 1.7-14 ug/dL
Full Term Day 7: 2.0-11 ug/dL
31 days-11 months: 2.8-23 ug/dL
12 months-15 years (8 a.m.): 3.0-21 ug/dL
Adults
8 a.m.: 8.0-19 ug/dL
4 p.m.: 4.0-11 ug/dL
Deoxycorticosterone (DOC):
Premature (26-28 weeks) Day 4: 20-105 ng/dL
Premature (34-36 weeks) Day 4: 28-78 ng/dLNewborn: Levels are markedly elevated at birth and decrease rapidly during the first week to the range of 7-49 ng/dL as found in older infants.
1 month-11 months: 7-49 ng/dL
Prepubertal Children: 2-34 ng/dL
Pubertal Children and Adults 8 a.m.: 2-19 ng/dL
Dehydroepiandrosterone (DHEA):
Premature (26-31 weeks): 82-1484 ng/dL
Premature (32-35 weeks): 56-1853 ng/dL
Full Term (2-7 days): 41-1292 ng/dL
8 days-5 months: <948 ng/dL
6 months-12 months: <136 ng/dL
1 year-5 years: <68 ng/dL
6-7 years: <111 ng/dL
8-10 years: <186 ng/dL
11-12 years: <202 ng/dL
13-14 years: <319 ng/dL
15-16 years: 39-481 ng/dL
17-19 years: 40-491 ng/dL
20-50 years: 31-701 ng/dL
>50 years: 21-402 ng/dL
11-Desoxycortisol:
Premature (26-28 weeks) Day 4: 110-1376 ng/dL
Premature (31-35 weeks) Day 4: 48-579 ng/dL
Full term Newborn Day 3: 13-147 ng/dL
1 month-11 months: <10-156 ng/dL
Prepubertal 8 a.m.: 20-155 ng/dL
Pubertal Children and Adults 8 a.m.: 12-158 ng/dL
17-OH Pregnenolone:
Premature (26-28 weeks) Day 4: 375-3559 ng/dL
Premature (31-35 weeks) Day 4: 64-2380 ng/dL
3 days: 10-829 ng/dL
1 month-5 months: 36-763 ng/dL
6-11 months: 42-540 ng/dL
12-23 months: 14-207 ng/dL
24 months-5 years: 10-103 ng/dL
6-9 years: 10-186 ng/dL
Pubertal: 44-235 ng/dL
Adults: 53-357 ng/dL
Progesterone:
Males
1 year-16 years: <10-15 ng/dL
Adults: <10-11 ng/dL
Females
1 year-10 years: <10-26 ng/dL
11 years: <10-255 ng/dL
12 years: <10-856 ng/dL
13 years: <10-693 ng/dL
14 years: <10-1204 ng/dL
15 years: <10-1076 ng/dL
16 years: <10-1294 ng/dL
Adult
Cycle days
1-6: <10-17 ng/dL
7-12: <10-135 ng/dL
13-15: <10-1563 ng/dL
16-28: <10-2555 ng/dL
Post Menopausal: <10 ng/dL
Note: Luteal progesterone peaked from 350 to 3750 ng/dL on days ranging from 17 to 23.
17-Alpha-Hydroxyprogesterone (17-OHP):
Premature (26-28 weeks) Day 4: 124-841 ng/dL
Premature (31-35 weeks) Day 4: 26-568 ng/dL
Full-Term Day 3: <78 ng/dL
Males:
Levels increase after the first week to peak values ranging from 40-200 ng/dL between 30 and 60 days. Values then decline to a prepubertal value of <91 ng/dL before one year.
Prepubertal: <91 ng/dL
Adult: 27-199 ng/dL
Females:
1 month-11 months: 13-106 ng/dL
Prepubertal: <91 ng/dL
Adult:
Follicular: 15-70 ng/dL
Luteal: 35-290 ng/dL
Testosterone, Total
Males:
Premature (26-28w) Day 4: 59-125 ng/dL
Premature (31-35w) Day 4: 37-198 ng/dL
Newborns: 75-400 ng/dL
1 month-7 months: Levels decrease rapidly the first week to 20-50 ng/dL, then increase to 60-400 ng/dL between 20 and 60 days. Levels then decline to prepubertal range levels of <2.5-10 ng/dL by seven months.
Females:
Premature (26-28w) Day 4: 5-16 ng/dL
Premature (31-35w) Day 4: 5-22 ng/dL
Newborns: 20-64 ng/dL
1 month-7 months: Levels decrease during the first month to less than 10 ng/mL and remain there until puberty.
Prepubertal Males and Females: <2.5-10 ng/dL
Adult
Males >18 years: 264-916 ng/dL
Females:
Premenopausal: 10-55 ng/dL
Postmenopausal: 7-40 ng/dL
Males
Tanner Stage 1 <9.8 years: <2.5-10 ng/mL
Tanner Stage 2 9.8 years-14.5 years: 18-150 ng/mL
Tanner Stage 3 10.7 years-15.4 years: 100-320 ng/mL
Tanner Stage 4 11.8 years-16.2 years: 200-620 ng/mL
Tanner Stage 5 12.8 years-17.3 years: 350-970 ng/mL
Females
Tanner Stage 1 <9.2 years: <2.5-10 ng/mL
Tanner Stage 2 9.2-13.7 years: 7-28 ng/mL
Tanner Stage 3 10.0-14.4 years: 15-35 ng/mL
Tanner Stage 4 10.7-15.6 years: 13-32 ng/mL
Tanner Stage 5 11.8-18.6 years: 20-38 ng/mL
Day(s) Performed
Monday, Wednesday
Report Available
10 to 19 daysPerforming Laboratory
Esoterix EndocrinologyCPT Code Information
82633 - DOC
82634 - 11-Desoxycortisol
82157 - Androstenedione
82533 - Cortisol
82626 - DHEA
84143 - 17-OH-Pregnenolone
84144 - Progesterone
83498 - 17-OH-Progesterone
84403 - Testosterone
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| FFCAH | CAH Profile 6 | Not Provided |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| Z5043 | Cortisol | 2143-6 |
| Z5044 | Deoxycorticosterone (DOC) | 1656-8 |
| Z5045 | 11-Desoxycortisol | 1657-6 |
| Z5046 | Dehydroepiandrosterone (DHEA) | 2193-1 |
| Z5047 | 17-OH Pregnenolone | 6765-2 |
| Z5048 | Progesterone | 2839-9 |
| Z5049 | 17-Alpha-Hydroxyprogesterone 17-OHP | 1668-3 |
| Z5050 | Androstenedione | 1854-9 |
| Z5051 | Testosterone, Total | 2986-8 |