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HelpCatalog ID CPAVP Copeptin proAVP, Plasma
Useful For
Investigating the differential diagnosis for patients with water balance disorders, including diabetes insipidus, in conjunction with osmolality and hydration status
May aid in the evaluation of cardiovascular disease in conjunction with other cardiac markers
Specimen Required
Patient Preparation: For water-deprivation testing, for at least 8 hours, the patient should fast and thirst (no liquids, including water, are allowed).
Collection Container/Tube: Lavender top (EDTA)
Submission Container/Tube: Plastic screw-top vial
Specimen Volume: 0.5 mL
Collection Information: Centrifuge and aliquot plasma into a plastic vial. Do not submit in original tube.
Collect 1.5 mL blood in Purple top tube. Patient must be fasting and no liquids, including water, for a minimum of 8 hours prior to draw.
Reference Values
Non-water deprived, non-fasting adults*: <13.1 pmol/L
Water deprived, fasting adults**: <15.2 pmol/L
Non-water deprived, non-fasting pediatric patients***: <14.5 pmol/L
Note:
*Keller T, Tzikas S, Zeller T, et al. Copeptin improves early diagnosis of acute myocardial infarction. J Am Coll Cardiol. 2010;55(19):2096-2106. doi:10.1016/j.jacc.2010.01.029
**Internal Mayo Clinic study
***Du JM, Sang G, Jiang CM, He XJ, Han Y. Relationship between plasma copeptin levels and complications of community-acquired pneumonia in preschool children. Peptides. 2013;45:61-65. doi:10.1016/j.peptides.2013.04.015
Specimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma EDTA | Refrigerated (preferred) | 7 days | |
| Frozen | 30 days | ||
| Ambient | 7 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Day(s) Performed
Monday through Saturday
Specimen Type
Plasma EDTAPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Method Name
Immunofluorescent Assay (IFA)
Reporting Name
Copeptin proAVP, PSecondary ID
603599Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
84588
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CPAVP | Copeptin proAVP, P | 78987-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| CPAVP | Copeptin proAVP, P | 78987-5 |