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HelpCatalog ID CORTC Corticosterone, Serum
Useful For
Diagnosis of suspected 11-hydroxylase deficiency, including the differential diagnosis of 11-beta-hydroxylase 1 (CYP11B1) versus 11-beta-hydroxylase 2 (CYP11B2) deficiency, and the diagnosis of glucocorticoid-responsive hyperaldosteronism
Evaluating congenital adrenal hyperplasia newborn screen-positive children, when elevations of 17-hydroxyprogesterone are only moderate, thereby suggesting possible 11-hydroxylase deficiency
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions:
1. Morning (8 a.m.) specimen is preferred.
2. Centrifuge and aliquot serum into a plastic vial.
Collect 1.2 mL blood in Red top tube.
Reference Values
≤18 years: 18-1,970 ng/dL
>18 years: 53-1,560 ng/dL
Specimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 14 days |
Special Instructions
Testing Algorithm
For more information see Steroid Pathways.
Day(s) Performed
Tuesday
Specimen Type
SerumTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.Performing Laboratory
Mayo Clinic Laboratories in Rochester
Reporting Name
Corticosterone, SCPT Code Information
82528
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CORTC | Corticosterone, S | 2139-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 88221 | Corticosterone, S | 2139-4 |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)