Sign in →

Catalog ID Auto Neuro Autoimmune Neurologic Disease Panel with Reflex, Serum

Additional Codes

CPOE: Ref Autoimmune Neurologic Disease Panel with Reflex, Serum

DOE: Ref Auto Neuro

Specimen

Gold SST tube, collect 8 mL blood

Centrifuge within 2 hours of collection

Serum, four (4) 1.0 mL aliquots in separate transport tubes, frozen

Rejection Criteria

Plasma, CSF, amniotic fluid, ocular fluid, peritoneal fluid, synovial fluid, contaminated specimen, grossly hemolyzed specimen, icteric specimen, lipemic specimen, insufficient quantity, unlabelled specimen

Interpretative Information

Comprehensive panel for the evaluation of paraneoplastic and neuromuscular junction disorders, and/or encephalitis, in the presence or absence of malignancy.

If N-methyl-D-Aspartate Receptor Antibody is positive, then titer will be performed. Additional charges apply.
If CV2.1 Antibody IgG Screen by IFA is positive, then titer will be performed, and Acetylcholine Receptor Binding Antibody will be added. Additional charges apply.
If AQP4 antibody IgG is positive, then titer will be added. Additional charges apply.
If PCCA/ANNA antibody IgG is screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be performed. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot will be performed. Additional charges apply.
If LGI1 antibody IgG is positive, then titer will be added. Additional charges apply.
If CASPR2 antibody IgG is positive, then titer will be added. Additional charges apply.
If AMPAR antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-BR antibody IgG is positive, then titer will be added. Additional charges apply.
If MOG antibody IgG is positive, then titer will be added. Additional charges apply.
If DPPX antibody IgG is positive, then titer will be added. Additional charges apply.
If ITPR1 antibody IgG is positive, then titer will be added. Additional charges apply.
If IgLON5 antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-AR antibody IgG is positive, then titer will be added. Additional charges apply.
If mGLUR1 antibody IgG is positive, then titer will be added. Additional charges apply.

Performing Lab

ARUP Laboratories

Turn-Around-Time

3-10 days (performed on Tuesdays)

Reference Values

Component Reference Interval
Neuronal Antibody (Amphiphysin) Negative
P/Q-Type Calcium Channel Antibody 24.5 pmol/L or less
Glutamic Acid Decarboxylase Antibody 0.0-5.0 IU/mL
N-methyl-D-Aspartate Receptor Ab, Serum Less than 1:10
Voltage-Gated Potassium Channel Ab, Ser 31 pmol/L or less
Purkinje Cell/Neuronal Nuclear IgG Scrn None Detected
CASPR2 Ab IgG Screen by IFA, Serum Less than 1:10
LGI1 Ab IgG Screen by IFA, Serum Less than 1:10
Neuromyelitis Optica/AQP4-IgG, Serum Less than 1:10
CV2.1 Antibody IgG Screen by IFA Less than 1:10
AMPA Receptor Ab IgG Screen, Serum Less than 1:10
GABA-B Receptor Ab IgG Screen, Serum Less than 1:10
MOG Antibody IgG Screen, Serum Less than 1:10
SOX1 Antibody, IgG by Immunoblot, Serum Negative
Ganglionic Acetylcholine Receptor Ab 8.4 pmol/L or less
DPPX Ab IgG CBA IFA Screen, Serum Less than 1:10
ITPR1 Ab IgG CBA-IFA Screen, Serum Less than 1:10
IgLON5 Ab IgG CBA-IFA Screen, Serum Less than 1:10
GABA-AR Ab IgG CBA-IFA Screen, Serum Less than 1:10
mGluR1 Ab IgG CBA-IFA Screen, Serum Less than 1:10
Voltage-Gated Potassium Channel (VGKC) Antibody, Serum 31 pmol/L or less: Negative
  32-87 pmol/L: Indeterminate
  88 pmol/L or greater: Positive
P/Q-Type Voltage-Gated Calcium Channel (VGCC) Antibody 0.0 to 24.5 pmol/L: Negative
  24.6 to 45.6 pmol/L: Indeterminate
  45.7 pmol/L or greater: Positive
Ganglionic Acetylcholine Receptor Antibody 0.0 - 8.4 pmol/L: Negative
  8.5 - 11.6 pmol/L: Indeterminate
  11.7 pmol/L or greater: Positive