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HelpCatalog ID 21DOC 21-Deoxycortisol, Serum
Useful For
As an adjunct to measurement of 17-hydroxyprogesterone, androstenedione, and cortisol in the diagnosis of difficult cases of suspected 21-hydroxylase (CYP21A2) deficiency
Identifying heterozygote CYP21A2 deficiency carriers
As an adjunct to measurements of 17-hydroxyprogesterone, androstenedione, testosterone, and, in female patients, estradiol in the follow-up of children with CYP21A2 deficiency
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions:
1. Morning (8 a.m.) specimen is preferred.
2. Centrifuge and aliquot serum into a plastic vial.
Collect 1.2 mL blood in Red top tube.
Reference Values
<5.0 ng/dL
Reference values apply to all ages.
Day(s) Performed
Tuesday
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
21-Deoxycortisol, SSpecimen Type
SerumSpecimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 21 days | |
| Frozen | 21 days | ||
| Ambient | 14 days |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Secondary ID
89477Testing Algorithm
For more information see Steroid Pathways.
Special Instructions
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82542
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| 21DOC | 21-Deoxycortisol, S | 74872-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 89477 | 21-Deoxycortisol, S | 74872-3 |